Activism Change

hCG for Kaposi's Sarcoma? Not!

Question:

Looks like the AIDS treatment established was wrong on yet another front due to its zeal to find a patentable treatment for something they didn’t take the time to understand at the basic science level in the first place! That’s what happens when priorities are upside-down (or "treatment activists" are dictating politics to the FDA). Frod,

First, let me explain George Carter’s embarassment for his use of the name "Frod". George confides that he suffers from seizures that are triggered when the surviving neuron assigned to the role of speech encounters certain word sounds, such as "fred". Thus he assigns various alternatives, such as "Frod". Isn’t it amazing how God blessed the handicapped with so many ways to overcome their challenges? …you make the same mistake. If you want to wait until all the basic science data are safely in, hell will have frozen over.

Carter’s surviving neuron assigned to the task of logic has obviously atrophied due to inactivity. Of course, when one surveys the landscape and finds it littered with a decade of 360,000+ American corpses who were rushed into the cancer anti-virus drug "standard of care" (which was neither standard, nor was it care) — one will see that indeed, hell has frozen over. If poor Carter could train all of his remaining mental midgetry upon the lessons learned from cancer, he might discover how 100% wrong he is to embrace the concept of "treatment before science". You see, the strategy Carter prefers is no different than writing all the code for a computer program before the analysis and design phase. The real world doesn’t work like that and never has.

This is George’s view of his world. If he actually completed some formal education, perhaps he could see things differently. Unfortunately, he hasn’t the discipline to exceed his "flat earth" mentality. A certain level of risk is inherent.

Not for you, George. You aren’t HIV+ !!! Understanding and trying to minimize toxicity risks can certainly help.

Too bad this hasn’t happened. Nice concept though! If we, as a society, had waited until we knew all the basic science of beta-lactams, we never would have used any antibiotics.

Unfortunately, George doesn’t know his medical history. If he would spend a little time doing his homework before screeching like an activist, he would see the development of antibiotic therapy from a different perspective entirely. Here — let’s try a much better example much more appropriate to Carter’s defective logic:    If we has waited until the protease inhibitors, we never    would have used any cancer drugs like AZT. There. That’s much easier to understand, wouldn’t you agree, George? The risk that wasn’t addressed was overuse and now we face multi-drug resistant strains.

Oh my. Looks like Mr. Science never spent time with George! The incorrect logic here is that resistant strains only result from overuse — what’s hysterical about this example is that George’s world seems to recognize resistance in terms of underuse, not overuse. A genuine no brainer. But that doesn’t abrogate the clinical and scientific value of antibiotic drug therapy has had for millions of lives.

Missing the point of the post altogether, Carter fails to grasp the evil concept of human experimentation for the hell of it! Thus his avoidance of hCG and KS or the drug crusader’s political buffoonery. George weaves his parrot-like linguistic mimicry into his faulty logic and then concludes his irrational ramblings with some obvious conclusion that is usually irrelevant to his discussion altogether. In other words, after a spasm of Carter’s typically uneducated bullshit, he always ends up babbling about something even the common-folk understand. Carter needs to do this to convince himself he is on the right track because Carter secretly knows that his chaotic opinions are actually facts that have yet to be discovered — facts of divine origin. I pity you Frod.                 George M. Carter

Someone who has divine inspiration pitys everyone, even those whose names inspire their childish taunts. Let’s take a look into Carter’s divine inspiration:    "I joined ACT UP in 1989 because I knew I needed     to do something with my life to replace the heroin habit." To wit, I direct George to turn his pity and activism addiction towards the effort of recovery and therapy … until George can become a whole person, his efforts to "help" others will remain destructive. fred

Response:

diatribe snipped… Here — let’s try a much better example much more appropriate to Carter’s defective logic:   If we has waited until the protease inhibitors, we never   would have used any cancer drugs like AZT. There. That’s much easier to understand, wouldn’t you agree, George?

No. I really don’t understand the statement (faulty syntax aside). In fact your post was so filled with internal contradictions that it is clearly hopeless to try to have a sensible discussion. I say one thing, you say the opposite and imply that’s what I said. Or otherwise twist, distort and mangle. Your habit  of irrelevant personal attacks serve no value but underscore your schoolyard bully nature.                 George M. Carter

Response:

diatribe snipped… Here — let’s try a much better example much more appropriate to Carter’s defective logic:   If we has waited until the protease inhibitors, we never   would have used any cancer drugs like AZT. There. That’s much easier to understand, wouldn’t you agree, George? No. I really don’t understand the statement (faulty syntax aside).

My oh my, it seems that George snipped away his first heroin-tortured comparison — George, I know these are difficult issues for you, but you’ll spare yourself a bit of embarassment if you stop playing with those scissors! Here, I found it! let’s paste it back in and take a fresh look: If we, as a society, had waited until we knew all the basic science of beta-lactams, we never would have used any antibiotics. Unfortunately, George doesn’t know his medical history. If he would spend a little time doing his homework before screeching like an activist, he would see the development of antibiotic therapy from a different perspective entirely. Here — let’s try a much better example much more appropriate to Carter’s defective logic:    If we had waited until the protease inhibitors, we never    would have used any cancer drugs like AZT. fact your post was so filled with internal contradictions that it is clearly hopeless to try to have a sensible discussion.

George Carter having a sensible discussion is an oxymoron, not unlike the term "legally drunk". I say one thing, you say the opposite and imply that’s what I said.

Not when I quote you, it isn’t. The fact is, you are a pathological liar who can’t seem to keep track of all the fantastic lies! Or otherwise twist, distort and mangle.

I can understand why the reality looks this way to you, George. It goes with the territory. Your habit  of irrelevant personal attacks serve no value but underscore your schoolyard bully nature.                 George M. Carter

Personal attacks? You’re projecting again, George! Is that why you forgot to call me "Frod"? Here’s a recent quote from George The Humanitarian of December 8, 1997:    "This type of sleazy distortion is typical of you Frod.     (Oh, oops, I forgot…you’re not Frod…you just another     cowardly shit with a yen to diss any treatment that works…     I wonder why you are really here?)" There you go … now THAT really helps AIDS along, doesn’t it George? Now what was that about personal attacks??? Hmmmm????? fred

Response:

Looks like the AIDS treatment established was wrong on yet another front due to its zeal to find a patentable treatment for something they didn’t take the time to understand at the basic science level in the first place! That’s what happens when priorities are upside-down (or "treatment activists" are dictating politics to the FDA).

Frod, you make the same mistake. If you want to wait until all the basic science data are safely in, hell will have frozen over.  The real world doesn’t work like that and never has.  A certain level of risk is inherent. Understanding and trying to minimize toxicity risks can certainly help. If we, as a society, had waited until we knew all the basic science of beta-lactams, we never would have used any antibiotics.  The risk that wasn’t addressed was overuse and now we face multi-drug resistant strains. But that doesn’t abrogate the clinical and scientific value of antibiotic drug therapy has had for millions of lives. I pity you Frod.                 George M. Carter

Response:

Looks like the AIDS treatment established was wrong on yet another front due to its zeal to find a patentable treatment for something they didn’t take the time to understand at the basic science level in the first place! That’s what happens when priorities are upside-down (or "treatment activists" are dictating politics to the FDA). fred Lancet – Saturday 13 December 1997, Volume 350, Number 9093 Pregnancy hormone acts on AIDS-related Kaposi’s sarcoma–or does it? Human chorionic gonadotrophin (hCG) has previously been shown to have activity against AIDS-related Kaposi’s sarcoma (KS) in vivo. But now, as US researchers report a phase-I trial of hCG in patients with KS, UK experts suggest that this clinical effect may not all be due to hCG. Parkash Gill (University of Southern California School of Medicine, Los Angeles, CA, USA) and colleagues studied three groups of six HIV-1-positive men with KS given crude hCG (made from the urine of pregnant women). Two patients given 5000 IU hCG daily and two given 10 000 IU three times a week had at least a 50% reduction in tumour burden. Two patients given 10 000 IU daily had complete remission. Disease stabilised in nine other patients (J Natl Cancer Inst 1997; 89: 1797-1802). But in other studies, purified or recombinant hCG has had no anti-KS effects. New work by Suzanne Griffiths (University of Leeds, UK) and co-workers may explain this paradox (Nature 1997; 390: 568). They report the purification from a commercial hCG preparation of a ribonuclease which has "potent dose-dependent killing activity" against a KS cell line. A related amphibian enzyme, onconase, is in phase-III trials for pancreatic carcinoma. It may be possible, say the authors, to use the antineoplastic properties of human urinary ribonuclease "as part of a new regime for the treatment of AIDS-related KS and other tumours". Kelly Morris HIV-1 infection puzzles Denmark A 6-year-old girl has contracted HIV-1 while being treated for leukaemia at a hospital in Aalborg, Denmark. Experts are considering the case as perhaps the first patient-to-patient transmission of HIV-1. The national Statens Serum Institut has compared the genetic fingerprint of the girl’s virus with that of another known HIV-1-posiitive child on the ward, and f rl must have been infected from the other child. What remains uncertain is how the virus was transmitted. Hospital authorities claim that all procedures were strictly followed, and that they have no reason to suspect staff malpractice. Transmission via donated blood products has been excluded. "Maybe one child bit the other during play", says hospital manager Jesper Christensen. No incidence of biting or scratching has, however, been recorded, and specialists elsewhere suspect a staff error–perhaps a dirty syringe. Hints from hospital management that this could be an example of a hitherto unknown means of transmision have been met with absolute disbelief from experts outside Aalborg. Kaare Skovmand Antiretrovirals planned for developing world Doctors in Uganda and C

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